The ghetto in Glubokoye was established in November 1941. In addition to the local community, Jews from the surrounding towns of Szarkowszczyzna, Postawy and Plissa were moved into the ghetto, swelling its population to 6,000. The ghetto population was divided between those deemed fit for labor, who were put to work in numerous ghetto workshops, and those who were not. On March 25, 1942, 105 Jews were rounded-up and shot. Three months later on June 19, 2,500 Jews who were considered unfit for work were killed in the nearby Borek Forest. In 1943 when the Germans began to fear that the ghetto might try to establish contact with nearby partisan units, they ordered the liquidation of the ghetto. On August 20, 1943, members of the Jewish council were ordered to organize the Jews for deportation. Upon entering the ghetto, the Germans met with armed resistance by Jewish groups. To suppress the revolt, the Germans set the ghetto on fire. About sixty Jews from Glubokoye survived the Holocaust.